Double Action
Pain Relief
Combogesic® is a proven combination of acetaminophen and ibuprofen that provides fast, effective dual action pain relief from a wide range of pain.
Acetaminophen acts mainly in the brain, while ibuprofen targets the production of pain chemicals throughout the body and reduces inflammation.
Put Combogesic® to the test for your pain
Faster, more effective pain relief than acetaminophen or ibuprofen alone1,*
Proven to provide more effective pain relief in a key study
More effective pain relief than acetaminophen alone1,*
More effective pain relief than ibuprofen alone1,*
Faster onset of meaningful pain relief than acetaminophen or ibuprofen alone1,*
More effective pain relief in the first 6 hours than acetaminophen or ibuprofen alone1,*
Combogesic® (Acetaminophen/Ibuprofen)
is indicated in adults over 18 years for the:
- Short term management of mild to moderate acute pain
- Reduction of fever
Opioid-Free
Combogesic® is opioid-free and is clinically proven to reduce the need for opioids in managing pain1,*, providing an effective alternative for those considering OTC pain relief medications containing opioids (e.g. codeine)
Serious Warnings and Precautions
If you have, or previously had, any of the following medical conditions, see your health care provider to discuss treatment options other than Combogesic®:
- Heart attack or angina
- Stroke or mini-stroke
- Loss of vision
- Current pregnancy (less than 28 weeks)
- Congestive Heart Failure
Combogesic® may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal.
Combogesic® is contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Stomach bleeding warning: This product may cause stomach bleeding. Symptoms may include feeling faint, vomiting blood, bloody or black stools. The chance of stomach bleeding is higher if you:
- are aged 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinner or steroid drug
- take with other drugs containing an NSAID like acetylsalicylic acid (ASA), ibuprofen, naproxen, or prescription anti-inflammatory drugs
- have 3 or more alcoholic drinks every day while using this product
Talk to your doctor if you are trying to conceive, in your first or second trimester of pregnancy or if breastfeeding. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless directed by a doctor because it may cause problems in the unborn child or complications during delivery.
Liver warning: Combogesic® contains acetaminophen, which has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with doses of acetaminophen that exceed 4,000 milligrams per day.
Severe or possibly fatal liver damage may occur if you take:
- more than the recommended dose in 24 hours
- with other drugs containing acetaminophen
- while drinking three (3) or more alcoholic drinks every day.
Symptoms of liver damage may include yellowing of the skin/eyes, dark urine, nausea, vomiting, stomach pain, unusual tiredness, and/or loss of appetite.
Allergy alert: Acetaminophen may cause serious skin reactions. Symptoms may include skin reddening, blisters, or rash. If any of the above noted symptoms occur, stop use and seek medical help right away.
*These claims are based on the maximum 3 tablet dose. The standard dose is 1-2 tablets – 3 if advised by your doctor.
1. Daniels SE, Atkinson HC, Stanescu I, Frampton C. Analgesic efficacy of an acetaminophen/ibuprofen fixed-dose combination in moderate to severe postoperative dental pain: a randomized, double-blind, parallel-group, placebo-controlled trial. Clin Ther. 2018;40(10):1765–1776.