COMBOGESIC® provides
fast, effective pain relief
from a wide range of pain
Acetaminophen acts mainly in the brain, while ibuprofen targets the production
of pain chemicals throughout the body and reduces inflammation.
Effectively reduces pain
Combogesic® provides 78% more effective pain relief than acetaminophen alone and 36% more effective than ibuprofen alone1,*.
Easy dosing regime
For the short-term management of mild to moderate acute pain and the reduction of fever, the recommended adult dose of Combogesic® is 1-2 tablets every 6 hours.
If pain or fever does not respond to 2 tablets, 3 tablets may be taken at subsequent doses, but only on the advice of a physician. Do not exceed 12 tablets over a 24-hour period.
Pediatrics
Pediatrics (< 18 years): No data are available to Health Canada; therefore, Health Canada has not authorized an indication for pediatric use.
Geriatrics
Geriatrics (> 65 years of age): Evidence from clinical studies and experience suggests that use in the geriatric population is associated with differences in safety or effectiveness and a brief discussion can be found in the appropriate sections of the product monograph found at: View Product Monograph here.
No adjustment in labelled dosage is necessary for older patients, who require acetaminophen therapy. Those who require therapy for longer than 3 days should consult their physician for condition monitoring; however, no reduction in recommended dosage is necessary. However, caution should be taken with regard to the use of ibuprofen as it should not be taken by adults over the age of 65 without consideration of co-morbidities and co-medications because of an increased risk of adverse effects, in particular heart failure, gastrointestinal ulceration and renal impairment.
Serious Warnings and Precautions
If you have, or previously had, any of the following medical conditions, see your health care provider to discuss treatment options other than Combogesic®:
- Heart attack or angina
- Stroke or mini-stroke
- Loss of vision
- Current pregnancy (less than 28 weeks)
- Congestive Heart Failure
Combogesic® may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal.
Combogesic® is contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Stomach bleeding warning: This product may cause stomach bleeding. Symptoms may include feeling faint, vomiting blood, bloody or black stools. The chance of stomach bleeding is higher if you:
- are aged 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinner or steroid drug
- take with other drugs containing an NSAID like acetylsalicylic acid (ASA), ibuprofen, naproxen, or prescription anti-inflammatory drugs
- have 3 or more alcoholic drinks every day while using this product
Talk to your doctor if you are trying to conceive, in your first or second trimester of pregnancy or if breastfeeding. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless directed by a doctor because it may cause problems in the unborn child or complications during delivery.
Liver warning: Combogesic® contains acetaminophen, which has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with doses of acetaminophen that exceed 4,000 milligrams per day.
Severe or possibly fatal liver damage may occur if you take:
- more than the recommended dose in 24 hours
- with other drugs containing acetaminophen
- while drinking three (3) or more alcoholic drinks every day.
Symptoms of liver damage may include yellowing of the skin/eyes, dark urine, nausea, vomiting, stomach pain, unusual tiredness, and/or loss of appetite.
Allergy alert: Acetaminophen may cause serious skin reactions. Symptoms may include skin reddening, blisters, or rash. If any of the above noted symptoms occur, stop use and seek medical help right away.
*These claims are based on the maximum 3 tablet dose. The standard dose is 1-2 tablets – 3 if advised by your doctor.
1. Daniels SE, Atkinson HC, Stanescu I, Frampton C. Analgesic efficacy of an acetaminophen/ibuprofen fixed-dose combination in moderate to severe postoperative dental pain: a randomized, double-blind, parallel-group, placebo-controlled trial. Clin Ther. 2018;40(10):1765–1776.