A: The recommended COMBOGESIC® dose is 1-2 tablets every 6 hours. If pain or fever does not respond to 2 tablets, 3 may be taken at subsequent doses, but only on the advice of a physician. Do not exceed 12 tablets over a 24-hour period2. Do not use for pain for more than 5 days or fever for more than 3 days unless advised by a doctor.